pentobarbital will lessen the extent or impact of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Pitolisant publicity is decreased by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will reduce the level or effect of erlotinib by affecting hepatic/intestinal enzyme CYP3A4 metabo